Clinical Director, Oncology Clinical Development

Clinical Director, Oncology Clinical Development

Natera is seeking an experienced Clinical Director, Oncology Clinical Development to provide medical and scientific leadership for Natera-sponsored oncology clinical trials focused on minimal residual disease (MRD). In this pivotal role, you'll drive the design and execution of biomarker-driven interventional and randomized studies that integrate MRD testing into precision oncology strategies to support regulatory, scientific, and strategic objectives.

We're looking for an innovative clinical leader with deep oncology clinical development experience who thrives in a fast-paced, collaborative environment — and who's passionate about transforming cancer care. Natera's MRD platform is redefining precision oncology—enabling earlier detection, improved monitoring, and smarter treatment decisions. In this role, you'll lead studies that directly shape how cancer is managed worldwide, bringing actionable insights to clinicians and patients when they matter most.

What You'll Do

Clinical & Program Leadership

• Serve as the program-level medical lead for Natera-sponsored MRD clinical trials across assigned oncology indications, with ultimate accountability for clinical outcomes, data integrity, and patient safety.
• Define clinical development strategies that align study design, endpoints, and execution with regulatory and scientific objectives.
• Provide medical oversight across the full trial lifecycle, from design and protocol development through first patient in (FPI), data readout, and study close-out.

Study Design & Execution

• Provide strategic and medical guidance to Clinical Scientists, fostering collaboration on protocol design, data interpretation, and translational insights that drive clinical program success.
• Act as Medical Monitor, overseeing safety signal detection, adverse event review, and risk mitigation in compliance with GCP and regulatory requirements.

Cross-functional Leadership

• Partner with Regulatory Affairs, Medical Affairs, Biostatistics, and Clinical Operations to ensure seamless trial execution and regulatory alignment.
• Represent the clinical program in stakeholder meetings, regulatory submissions, and scientific forums.
• Mentor and develop clinical team members, fostering a culture of excellence and scientific rigor.

Key Requirements

• MD, DO, or equivalent terminal clinical degree with board certification or eligibility in relevant oncology specialty.
• Minimum 10+ years of oncology clinical development experience, including regulatory submissions, protocol design, and trial oversight in pharma, biotech, or CRO settings.
• Demonstrated expertise in MRD, biomarker-driven trial design, or precision oncology development.
• Strong understanding of FDA regulatory pathways, ICH-GCP guidelines, and clinical trial operations.
• Excellent written and verbal communication skills with ability to translate complex scientific concepts for diverse audiences.
• Proven ability to lead cross-functional teams and drive results in matrix environments.

💰 Compensation not publicly listed. Market estimate for similar roles: from $200K, varying by experience and location.